Ultimate Spider-Man #1 CGC 9.6 1st Ultimate Spider-Man
Ultimate Spider-Man #1 CGC 9.6. 1st Appearance of Ultimate Spider-Man and the Ultimate Marvel Universe. With a tip of the cap to established continuity the Ultimate Universe was free to update Marvel's biggest and best to reflect a more modern audience.
Some would argue if that was necessary but regardless this series was the cream of the crop.